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Molecular Pathogenesis

of HTLV-1
A Current Perspective
edited by O. John Semmes, Ph.D
and Marie-Louise Hammarskjöld, M.D., Ph.D

ISBN 1-886236-19-4 * 256pp, 7 x 10 * Hardcover * Illustrated * Acid Free Paper * $50.00

It has been almost two decades since the discovery of Human T-cell Leukemia Virus as the first human retrovirus linked to disease. The virus was first isolated from an individual suffering from an aggressive lymphoma and has since been conclusively linked to the development of Adult T-cell Leukemia (ATL). HTLV-1 infection has also been identified as the main etiological agent for a progressive neurodegenerative condition known as HTLV-1-associated myelopathy in Japan, and tropical spastic paraparesis in the Caribbean (HAM/TSP).
     In addition to ATL and HAM/TSP, the virus has also been associated with inflammatory disease, resulting in a cumulative lifetime risk of disease of about 10%. Given the widespread infections in areas of Japan, the Caribbean, and Africa, as well as the increasing incidence of infection in the United States and elsewhere, this virus warrants worldwide attention.
     Molecular Pathogenesis of HTLV-1 presents an updated perspective of our current knowledge of molecular events contributing to pathogenesis associated with HTLV-1. The book is divided into 5 sections with each section composed of multiple original research articles. Each article is written by a leading authority in the field. Issues addressed include progression to disease state, current disease models, and molecular events leading to pathogenesis. There are also two articles that provide a more general "layman’s" perspective.
     The goal of this book is to provide the reader with a "state-of-the-art" understanding of HTLV-1 research and to help identify areas needing additional attention.

Editors:

O. John Semmes, Ph.D.
Marie-Louise Hammarskjöld, M.D., Ph.D.
Department of Microbiology, Myles H. Thaler Center for AIDS and Human Retroviruses, University of Virginia School of Medicine, Charlottesville, VA, USA

Contributors:

John Brady, Ph.D. Laboratory of Receptor Biology & Gene Expression, NCI-NIH, Bethesda, MD, USA
David Derse, Ph.D.
Division of Basic Sciences, NCI-FCRDC, Frederick, MD, USA
Richard F. Edlich, M.D., Ph.D. Department of Plastic Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA
Gerold Feuer, Ph.D. Department of Microbiology & Immunology, SUNY Health Sciences Center, Syracuse, NY, USA
Genoveffa Franchini, Ph.D. Division of Basic Sciences, NCI-NIH, Bethesda, MD, USA
Masahiro Fujii, M.D., Ph.D. Dept. of Virology & Immunotherapeutics, Niigata University School of Medicine, Tokyo, Japan
Louis Gazzolo, M.D., Ph.D. Immuno-Virologie Moleculaire et Cellulaire, CNRS, Universite Claude Bernard Lyon I, Lyon, France
Ralph Grassmann, Ph.D. Institut fur Klinische und Molekulare Virologie, Universitat Erlangen-Nurnberg, Erlangen, Germany
Patrick L. Green, Ph.D. Department of Veterinary Biosciences & Medical Microbiology, Center for Retrovirus Research, Ohio State University, Columbus, OH, USA
Steven Jacobson, Ph.D. Viral Immunology Section, NINDS-NIH, Bethesda, MD, USA
Kuan-Teh Jeang, M.D., Ph.D. Laboratory of Molecular Microbiology, NIAID-NIH, Bethesda, MD, USA
Fatah Kashanchi, Ph.D. Department of Biochemistry & Molecular Biology, UMDNJ Medical School, Newark, NJ, USA
John P. Keegan, Chairman and President, Charles Edison Fund, Thomas Alva Edison Preservation Foundation, Orange, NJ, USA
Thomas Kindt, M.D., Ph.D, Division of Intramural Research, NIAID-NIH, Bethesda, MD, USA
Bernhard F. Maier, Ph.D. Department of Microbiology, Myles H. Thaler Center for AIDS and Human Retroviruses, University of Virginia School of Medicine, Charlottesville, VA, USA
Koshi Maruyama, M.D., Ph.D. Immunobiology Laboratory Co., Chiba, Japan
Jennifer K. Nyborg, Ph.D. Department of Biochemistry & Molecular Biology, Colorado State University, Fort Collins, CO, USA
Mitsuhiro Osame, M.D., Ph.D. Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
Lee Ratner, M.D., Ph.D. Departments of Medicine, Pathology & Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA
O. John Semmes, Ph.D. Department of Microbiology, Myles H. Thaler Center for AIDS and Human Retroviruses, University of Virginia School of Medicine, Charlottesville, VA, USA
Eric Wattel, M.D. INSERM, Institut de Recherche Sur le Cancer de Lille, Centre Oscar Lambert, Lille, France

 


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A Current Perspective  

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