MOLECULAR PATHOGENESIS OF HTLV-1
ISBN: 978-1-886236-19-6 •
256 pages • 7 x 10 • Illustrated • Acid Free Paper • $50.00
It has been almost two decades
since the discovery of Human T-cell Leukemia Virus as the first human
retrovirus linked to disease. The virus was first isolated from an
individual suffering from an aggressive lymphoma and has since been
conclusively linked to the development of Adult T-cell Leukemia (ATL).
HTLV-1 infection has also been identified as the main etiological agent
for a progressive neurodegenerative condition known as HTLV-1-associated
myelopathy in Japan, and tropical spastic paraparesis in the Caribbean
(HAM/TSP). In addition to ATL and HAM/TSP, the virus has also been
associated with inflammatory disease, resulting in a cumulative lifetime
risk of disease of about 10%.
Given the widespread infections
in areas of Japan, the Caribbean, and Africa, as well as the increasing
incidence of infection in the United States and elsewhere, this virus
warrants worldwide attention. Molecular Pathogenesis of HTLV-1
presents an updated perspective of our current knowledge of molecular
events contributing to pathogenesis associated with HTLV-1.
The book is divided into 5
sections with each section composed of multiple original research
articles. Each article is written by a leading authority in the field.
Issues addressed include progression to disease state, current disease
models, and molecular events leading to pathogenesis. There are also two
articles that provide a more general “layman’s” perspective.
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