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Molecular Pathogenesis of HTLV-1A CURRENT PERSPECTIVE

ISBN: 978-1-886236-19-6 • Hardcover
256 pages • 7 x 10 • Illustrated • Acid Free Paper • $50.00

It has been almost two decades since the discovery of Human T-cell Leukemia Virus as the first human retrovirus linked to disease. The virus was first isolated from an individual suffering from an aggressive lymphoma and has since been conclusively linked to the development of Adult T-cell Leukemia (ATL). HTLV-1 infection has also been identified as the main etiological agent for a progressive neurodegenerative condition known as HTLV-1-associated myelopathy in Japan, and tropical spastic paraparesis in the Caribbean (HAM/TSP). In addition to ATL and HAM/TSP, the virus has also been associated with inflammatory disease, resulting in a cumulative lifetime risk of disease of about 10%.

Given the widespread infections in areas of Japan, the Caribbean, and Africa, as well as the increasing incidence of infection in the United States and elsewhere, this virus warrants worldwide attention. Molecular Pathogenesis of HTLV-1 presents an updated perspective of our current knowledge of molecular events contributing to pathogenesis associated with HTLV-1.

The book is divided into 5 sections with each section composed of multiple original research articles. Each article is written by a leading authority in the field. Issues addressed include progression to disease state, current disease models, and molecular events leading to pathogenesis. There are also two articles that provide a more general “layman’s” perspective.


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